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Antipsychotics Linked to Increased Risk of Kidney Injury

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Jarod Cassidy3 years ago

Healthcare experts are calling for a reevaluation of the use of atypical antipsychotic medications to treat certain patient populations following new data that suggests the drugs could result in an increased risk for acute kidney injury.

About the Antipsychotic Study

According to Medscape, elderly patients are more likely to experience atypical antipsychotic meciations such as Seroquel (quetiapine), Risperdal (risperdone), Abilify (aripiprazole), and olanzapine.

An analysis of medical records for nearly 200,000 adults over the age of 64 showed that those patients who received such medications were twice as likely to be hospitalized for acute kidney injury within 90 days as those who did not take the drugs.

Further, patients who too even one oral atypical antipsychotic were at an increased risk of acute urinary retention, hypotension and death.

Reevaluating Antipsychotic Prescriptions

“We wanted to raise awareness around this issue and recommend that physicians should be cautious around the use of these medications in the elderly.” – Amit X. Garg, MD, PHD as published by Medscape Medical News

The authors of the study are asking that physicians and healthcare providers reevaluate the prescribing of atypical antipsychotics to older adults.

Further, the investigators warned against the off-label prescribing of the medications. Data showed that of 97,777 adults aged 65 years or older being treated with atypical antipsychotics, 53.8 percent were receiving the drug for dementia – an unapproved indication.


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