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Archillion Hepatitis Drug Raises Concern over Liver Injuries

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Jarod Cassidy4 years ago

As pharmaceutical companies race to get FDA approval on new hepatitis C drugs, a clinical trial hold placed on Archillion's ACH-3102 due to abnormal liver enzyme levels may mark the end of the drug. However, like many companies, Archillion has more hepatitis C drugs in the pipeline.

Archillion Pharmaceutical Clinical Trial Hold

  • According to Bloomberg, a hepatitis drug by Archillion Pharmaceutical Inc. (ACH-3102) has been placed on hold by U.S. regulators.
  • The hold is in response to reports of elevated enzymes in a trial in which the drug was combined with two medications used in the treatment of HIV.
  • Elevated enzymes can represent an irregularity which may result in renal injury or even death.
  • Though one clinical trial is on hold, Archillion still has two other hepatitis C drugs in the pipeline.

Market Shares Fall as Clinical Trial is Placed on Hold

  • With an estimated market worth of $20 billion, the development of a new hepatitis C drug would mean huge profits for both a pharmaceutical company and that company’s investors.
  • Further, with so many companies racing to develop a new hepatitis C drug, a clinical trial hold often spells doom for a potential drug as market shares begin to drop.
  • As Archillion’s ACH-3102 was place on hold, the company saw a 25% decline in shares.
  • Similarly, Vertex saw a 19% decline with its last hold and Idenix a 30% drop.
Hepatitis C Drugs Currently in Clinical Development

According to HCV Advocates, 12 pharmaceutical companies currently have 28 hepatitis C drugs in clinical trials.

  •     Achillion
  •     AbbVie
  •     Boehringer Ingelheim
  •     Bristol Myers-Squibb
  •     Genentech
  •     Gilead
  •     Merck
  •     Tibotec
  •     Janssen Pharmaceuticals
  •     Vertex
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