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Anti-Inflammatory Pills Pose Heart Failure Risk

Kati Scanlon4 years ago

defective drugs

According to Reuters Health, a recent study has linked non-steroidal anti-inflammatory drugs (NSAIDs) to an increase in the risk of heart failure.

Details of How NSAIDs are Linked to Heart Failure

Previous studies of NSAIDs have shown a link between the pills and an increased risk of heart failure; however, the current study has shown new information on specific drugs within this family of medicine.

For the current study research analyzed data, from 1999 to 2010, of adults from Netherlands, Germany, U.K., and Italy. The analysis encompassed more than 92,000 individuals who were admitted to the hospital for heart failure. A group of more than 8.2 million individuals, who weren’t hospitalized for the condition, was then used as a control group.

The study found that 17.4 percent of individuals that were hospitalized for heart failure currently took NSAIDs. 14.4 percent of individuals without the condition were also currently taking the drug.

NSAIDs With Strongest Link to Heart Failure

The following NSAIDs had a higher risk of heart failure for people currently taking the drug:

  • Ketorolac
  • Etoricoxib
  • Indomethacin
  • Rofecoxib
  • Piroxicam
  • Diclofenac
  • Ibuprofen
  • Nimuesulide
  • Naproxen

These nine drugs increased the risk of heart failure in both genders and regardless of if they had been previously diagnosed with the condition. In addition, individuals faced twice the risk, when compared to past users, of heart failures if they were on large doses of diclofenac, etoricoxib, indomethacin, piroxicam, and rofecoxib.

An aspect that has limited the data in this study is that researchers do not have data on individuals who utilize over-the-counter NSAIDs, such as ibuprofen. This factor could understate the impact NSAIDs have on heart failure.

The findings from the study only add to the case that ties NSAIDs to the risk of heart failure, so users are advised to remain vigilant. Acetaminophen, or paracetamol, do not carry the same risk as NSAIDs, so for individuals suffering from pain these can be an alternative.

Other Risk Factors for Heart Disease

According to the Centers for Disease Control and Prevention (CDC), the following can also increase your risk of heart disease:

  • Coronary heart disease
  • Heart attacks
  • Diabetes
  • High blood pressure
  • Being overweight
  • Smoking tobacco
  • Not enough physical activity


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