According to NBC San Diego, the fatal crash occurred just after midnight Tuesday when a gray pickup truck traveling in the wrong direction struck a Mercedes Sedan.
The crash resulted in a fire, and both drivers were killed. There were no passengers in either car.
California Highway Patrol said they received a call concerning the truck driving the wrong-way about a minute before the fatal crash was reported.
The accident remains under investigation.
The following information was provided by the National Highway Traffic Safety Administration (NHTSA):