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Ceftriaxone Linked to Renal Failure in Children

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Jarod Cassidy4 years ago

According to Medscape, researchers have determined that ceftriaxone (Rocephin) used at therapeutic doses can lead to an increased risk of kidney stones and acute renal failure in children.

About Ceftriaxone

Ceftriaxone is an antibiotic used to treat a number of childhood infections, but resent data published in the medical journal Pediatrics has linked the compound to biliary pseudolithiasis, nephtolithiasis and bladder sludge.

Additionally, treatment with the drug was also found to cause the formation of urine crystals that cling to renal tubular cells, potentially causing acute renal failure.

This has lead to concerns over the drug's safety and the recommendation that children being treated with ceftriaxone be watched closely for any symptoms that may suggest renal impairment.

About the Ceftriaxone Study

“Ceftriaxone therapy in children may cause [Pediatric Acute Renal Failure]. Early diagnosis and prompt pharmcological therapy are important in relieving the condition.” – Authorial note as published by Medscape

The study looked at 31 cases of pediatric acute renal failure (PARF) after that developed after treatment with ceftriaxone between January 1, 2013 and June 30, 2012. Children who had no previous history of urolihiasis or nephropathy were included in the therapy.

Nine of the children were able to recover from PARF after one to four days of pharmacotherapy. The other twenty-two children required retrograde ureteral catherdization with one child requiring three sessions of hemodialysis to recover.

Based on these findings, the authors of the study advise that treatment with ceftriaxone be discontinued immediately upon observation of sudden-onset anuria or flank pain in children.

Other Side Effects of Ceftriaxone

In addition to renal failure and kidney stones, ceftriaxone has also been linked to:

  • Rash
  • Anaphylactic shock
  • Toxic epidermal necrolysis
  • Hypotension
  • Cardiac arrest
  • Hypersensitivity
  • Respiratory failure
  • Convulsion
  • Hemorrhage
  • Death


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