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Long-Term Use of Sorafenib May Cause Irreversible Pancreatic Atrophy

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Nick Naughton4 years ago

Two patients who had been using the drug sorafenib (Nexavar, Bayer/Onyx) over several years have developed pancreatic atrophy, the New England Journal of Medicine reports.

Sorafenib and Pancreatic Atrophy

  • According to MedScape, sorafenib is an oral inhibitor of vascular endothelial growth factor (VEGF) and used to treat kidney and liver cancers.
  • One researcher writes that long-term use of the drug “could cause cumulative, serious, and life-threatening late toxic effects.”
  • One of the patients had been taking the drug for 2.5 years and the other for 3 years. A volumetric CT of their abdomens showed a 20% reduction in the volume of the pancreas in one patient and a 35% reduction in the other .
  • The study has led to questions concerning the safety of VEGFs, if they can cause similar side effects and whether or not the benefit of the drug outweigh the risks.

Adverse Events Associated with Sorafenib

  • 17,925 adverse events have been reported to concerning sorafenib.
  • The most common adverse event reported with sorafenib were epidermal and dermal conditions.
  • Other possible adverse events tide to sorafenib include:

    • Palmar-plantar Erythrodysaesthesia Syndrome
    • Hypertension
    • Rash
    • Trouble Breathing
    • Liver Failure
    • Death
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