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NSAIDs Linked to Increased Atrial Fibrillation Risk

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Jarod Cassidy3 years ago

Researchers have determined that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of atrial fibrillation (AF).

76% Increase in AF Risk

According to Medscape, the study observed 8,423 participants from the Rotterdam Study – a population-based prospective cohort study which examined risk factors for diseases in older adults in the Ommoord district of Rotterdam, Netherlands.

The mean age of the study participants was 68.5 years, and roughly 59 percent of the participants were women.

Of the 857 participants who developed AF, 261 had never used NSAIDs, 554 had used NSAIDs in the past and 42 were currently taking NSAIDs.

After adjusting for age, sex and multiple cardiovascular risk factors, researchers concluded that patients using NSAIDs for two to four weeks were 76 percent more likely to develop AF than those who had not been treated with the medications.

About NSAIDs

NSAIDs are common pain relief medicines given to more than 30 million Americans suffering from headaches, sprains and arthritis every day.

Common over the counter versions include:

  • Ibuprofen (Advil, Motrin, Nuprin)
  • Aspirin (Bufferin, Bayer, Excedrin)
  • Ketoprofen (Actron, Orudis)
  • Naproxen (Aleve)

Prescription medications include:

  • Daypro
  • Indocin
  • Lodine
  • Naprosyn
  • Relafen
  • Vimovo
  • Voltaren


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