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Avandia Linked to Life-Altering and Potentially Fatal Side-Effects

Avandia, a drug prescribed to treat Type-2 diabetes, has been widely-prescribed in the United States since its FDA approval in 1991. Last year alone, sales of Avandia earned its manufacturer (GlaxoSmithKline) $1.9 billion. Unfortunately, in the years since its approval, numerous studies, warnings, and reports have indicated that the diabetes drug can cause life-altering and potentially fatal side-effects and complications.


  • Bone fractures
  • Severe allergic reactions
  • Diabetic macular edema
  • Liver toxicity
  • Heart valve disease
  • Blood artery disease
  • Heart failure or damage
  • Heart attack
  • Stroke


2002– FDA calls for stronger warning labels on Actos and Avandia which include a warning of increased risk of congestive heart failure.

2005– GlaxoSmithKline and the FDA notify doctors that reports show Avandia may cause new or worsening diabetic macular edema, fluid retention in the eye that can cause vision impairment.

2007– FDA issues a Black Box warning about the potential increased risk for heart attacks associated with Avandia.

2007– GlaxoSmithKline sends out a “Dear Doctor” letter informing healthcare professionals of study findings that showed a “significantly” higher risk of bone fractures in women taking Avandia.

2011– FDA issues a Drug Safety Communication notifying the public of label changes to Avandia labels which would include information on the cardiovascular risks (including heart attack) associated with the diabetes drug.


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