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Study- Painkillers and Heart Problems

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susan_harr6 years ago

A new study published in the British Medical Journal found an increased risk of abnormal heart rhythms with use of prescription and non-prescription pain killers like Advil, Aleve, and Celebrex.

The Study

  • Analyzed link between Non-steroidal Anti-Inflammatory Drugs (NSAIDs) and COX 2 Inhibitors and atrial fibrillation or flutter (abnormal heart rhythm)
  • Included 32,602 patients with diagnosis of atrial fibrillation or flutter between 1999 and 2008 and 325,918 control cases
  • Measured NSAID/COX 2 Inhibitor use at the time of admission and before admission


  • Use of non-aspirin NSAIDs was associated with an increased risk of atrial fibrillation or flutter (abnormal heart rhythm).
  • Compared with non-users, the association was strongest for new users, with a 40-70% increase in relative risk (lowest for non-selective NSAIDs and highest for COX 2 inhibitors).
Effects of atrial fibrillation or flutter (abnormal heart rhythm)

According to the New York Presbyterian Hospital, atrial fibrillation is a type of arrhythmia where the heart beats erratically. Atrial flutter is where the heart beats rapidly but regularly.

  • The primary danger from these conditions is stroke because these arrhythmias prevent the atria from pumping blood effectively
  • About 15% of strokes occur in persons with atrial fibrillation
Common NSAIDs and COX 2 Inhibitors


  • Advil
  • Aleve
  • Motrin
  • Ibuprofin

COX 2 Inhibitor

  • Celebrex
Contact an Experienced Product Liability Attorney

Thomas J. Henry are leaders in the area of product liability litigation. Our Defective Drug and Products Division has extensive knowledge and resources in order to represent our clients efficiently and aggressively.

Your choice does matter. If you or a loved one has suffered serious injuries because of any defective drugs and/or products, call Thomas J. Henry immediately. We are available 24/7, nights and weekends.


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