According to initial reports, the deadly crash happened about an hour after a tanker had rolled over, causing a chemical spill.
Police say the driver was Dr. Mallik Chaganti, 45 of Rensselaer, Indiana. The children killed have only been identified as a boy and girl.
The driver of the semi, whose identity has not been released, was uninjured in the accident. Authorities are investigating the crash but say alcohol and drugs are not suspected factors.
The Indiana State Police provide the following auto accident statistics.