According to the San Antonio Express-News, the accident occurred under the Interstate 10 overpass shortly before 4 am Wednesday.
The cab of the FedEx truck burst into flames upon impact – the driver, 39-year-old Brandon Joseph Biagas, was found dead inside the cab after the fire was extinguished.
While investigators have yet to determine what caused the truck to lose control, Sgt. Andrew Ling of the San Antonio Police Department says the accident may be linked to driver fatigue.
A witness at the scene told police the truck had been drifting between lanes for several miles; no other vehicles were near the truck when it veered off the roadway and into the guardrail and column.
Westbound lanes of Loop 410 were closed until noon. The interstate overpass sustained massive fire damage.