According to KEYE-TV, the crash occurred around 1:20 am at the intersection of SH 21 and Laredo Drive.
The scene was described as a head-on collision. Two people were pinned in one of the vehicles and were pronounced dead at the scene.
At least one of the vehicles caught fire after the crash.
Authorities are still investigating the incident.
The following information was provided by the Texas Department of Transportation (TxDOT):