According to FOX Carolina, the crash occurred in the Gateway Project construction zone on Interstate 385 just after 5 am.
Police say an 18-wheeler, a pickup truck, and a car were stopped on the interstate when another tractor-trailer struck the vehicles from behind. The oncoming semi first struck the pickup, sending it down an embankment, before hitting the car and pushing it under the stopped tractor-trailer.
The driver and a passenger in the car were pronounced dead at the scene. They have been identified as Dorothy Michelle Carroll, 40, and Jesse Robert Carroll, 50, respectively. Another passenger was rushed to the hospital with severe injuries.
The driver of the pickup was transported to the hospital in stable condition, and one of the truck drivers was also injured in the wreck.