According to WVTM 13, the crash occurred Thursday morning in the northbound lanes of Interstate 65 near Reverend Abraham Woods Jr. Boulevard.
The 18-wheeler first struck a stalled vehicle before colliding with another car and overturning on to its side. The overturned tractor-trailer blocked all lanes of traffic except for one.
Police have confirmed that one person was taken to the hospital with unknown injuries. The crash remains under investigation.