According to the Star Tribune, the fatal crash occurred on Interstate 94 around 5:44 pm Thursday.
Police say a wrong-way driver slammed into another vehicle, causing the second vehicle to catch fire and leaving its three occupants dead.
The wrong-way driver was transported to the hospital with critical injuries.
The names of those involved have not been released, and the crash remains under investigation.
The following information was provided by the National Highway Traffic Safety Administration (NHTSA):